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In Silico Insights into the Symbiotic Nitrogen Fixation in Sinorhizobium meliloti via Metabolic Reconstruction

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by Hansheng Zhao, Mao Li, Kechi Fang, Wenfeng Chen, Jing Wang

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1 day 23 hours ago
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Mitogen- and Stress-Activated Kinase 1 (MSK1) Regulates Cigarette Smoke-Induced Histone Modifications on NF-κB-dependent Genes

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by Isaac K. Sundar, Sangwoon Chung, Jae-woong Hwang, John D. Lapek, Michael Bulger, Alan E. Friedman, Hongwei Yao, James R. Davie, Irfan Rahman

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1 day 23 hours ago
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Sleep deprivation tied to increased nighttime urination in preadolescence

http://www.eurekalert.org

(American Physiological Society) Study sheds light on why some children may need to urinate more often during the rest cycle. Researchers found sleep deprivation caused healthy children, ages 8-12, to urinate significantly more frequently, excrete more sodium in urine, and have altered regulation of the hormones important for excretion.

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1 day 23 hours ago
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Road runoff spurring spotted salamander evolution

http://www.sciencedaily.com

Spotted salamanders exposed to contaminated roadside ponds are adapting to their toxic environments, according to new research. The study provides the first documented evidence that a vertebrate has adapted to the negative effects of roads apparently by evolving rapidly.

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1 day 23 hours ago
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A miR-1207-5p Binding Site Polymorphism Abolishes Regulation of HBEGF and Is Associated with Disease Severity in CFHR5 Nephropat

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by Gregory Papagregoriou, Kamil Erguler, Harsh Dweep, Konstantinos Voskarides, Panayiota Koupepidou, Yiannis Athanasiou, Alkis Pierides, Norbert Gretz, Kyriacos N. Felekkis, Constantinos Deltas

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1 day 23 hours ago
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Prolific plant hunters provide insight in strategy for collecting undiscovered plant species

http://www.eurekalert.org

(Missouri Botanical Garden) Today's alarmingly high rate of plant extinction necessitates an increased understanding of the world's biodiversity. An estimated 15 to 30 percent of the world's flowering plants have yet to be discovered, making efficiency an integral function of future botanical research.

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1 day 23 hours ago
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A Piezoelectric Immunosensor Using Hybrid Self-Assembled Monolayers for Detection of Schistosoma japonicum

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by Shiping Wang, Tieqiu Yin, Shaohua Zeng, Hongli Che, Feifei Yang, Xiuchun Chen, Guoli Shen, Zhaoyang Wu
Background The parasite Schistosoma japonicum causes schistosomiasis disease, which threatens human life and hampers economic and social development in some Asian countries. An important lesson learned from efforts to reduce the occurrence of schistosomiasis is that the diagnostic approach must be altered as further progress is made towards the control and ultimate elimination of the disease.

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1 day 23 hours ago
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Viremic HIV Infected Individuals with High CD4 T Cells and Functional Envelope Proteins Show Anti-gp41 Antibodies with Unique Sp

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by Marta Curriu, Hughes Fausther-Bovendo, María Pernas, Marta Massanella, Jorge Carrillo, Cecilia Cabrera, Cecilio López-Galíndez, Bonaventura Clotet, Patrice Debré, Vincent Vieillard, Julià Blanco
Background CD4 T-cell decay is variable among HIV-infected individuals. In exceptional cases, CD4 T-cell counts remain stable despite high plasma viremia. HIV envelope glycoprotein (Env) properties, namely tropism, fusion or the ability to induce the NK ligand NKp44L, or host factors that modulate Env cytopathic mechanisms may be modified in such situation.

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1 day 23 hours ago
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1

Predicting Target DNA Sequences of DNA-Binding Proteins Based on Unbound Structures

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by Chien-Yu Chen, Ting-Ying Chien, Chih-Kang Lin, Chih-Wei Lin, Yi-Zhong Weng, Darby Tien-Hao Chang

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1 day 23 hours ago
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