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Comparative Genomic Analysis of Pathogenic and Probiotic Enterococcus faecalis Isolates, and Their Transcriptional Responses to

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Urinary tract infection (UTI) is the most common infection caused by enterococci, and Enterococcus faecalis accounts for the majority of enterococcal infections.

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48 min 12 sec ago
Category: Biology   Tags:
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High-Density Genomewide Linkage Analysis of Exceptional Human Longevity Identifies Multiple Novel Loci

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Background

Human lifespan is approximately 25% heritable, and genetic factors may be particularly important for achieving exceptional longevity. Accordingly, siblings of centenarians have a dramatically higher probability of reaching extreme old age than the general population.

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48 min 24 sec ago
Category: Biology   Tags:
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The Distribution of GYR- and YLP-Like Motifs in Drosophila Suggests a General Role in Cuticle Assembly and Other Protein-Protein

http://www.plosone.org

Background

Arthropod cuticle is composed predominantly of a self-assembling matrix of chitin and protein. Genes encoding structural cuticular proteins are remarkably abundant in arthropod genomes, yet there has been no systematic survey of conserved motifs across cuticular protein families.

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48 min 35 sec ago
Category: Biology   Tags:
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Topoisomerase II-Mediated DNA Damage Is Differently Repaired during the Cell Cycle by Non-Homologous End Joining and Homologous

http://www.plosone.org

Topoisomerase II (Top2) is a nuclear enzyme involved in several metabolic processes of DNA. Chemotherapy agents that poison Top2 are known to induce persistent protein-mediated DNA double strand breaks (DSB).

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48 min 39 sec ago
Category: Biology   Tags:
1

High Amplitude Phase Resetting in Rev-Erbα/Per1 Double Mutant Mice

http://www.plosone.org

Over time, organisms developed various strategies to adapt to their environment. Circadian clocks are thought to have evolved to adjust to the predictable rhythms of the light-dark cycle caused by the rotation of the Earth around its own axis.

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48 min 50 sec ago
Category: Biology   Tags:
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Prediction and Testing of Biological Networks Underlying Intestinal Cancer

http://www.plosone.org

Colorectal cancer progresses through an accumulation of somatic mutations, some of which reside in so-called “driver” genes that provide a growth advantage to the tumor.

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49 min 15 sec ago
Category: Biology   Tags:

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