BiotechMashup

(Scripps Research Institute) A international team led by scientists from the Genomics Institute of the Novartis Research Foundation (GNF) and the Scripps Research Institute has discovered a family of chemical compounds that could lead to a new generation of antimalarial drugs capable of not only alleviating symptoms but also preventing the deadly disease.

Scientists have discovered a promising new drug candidate that represents a new class of drug to treat malaria. Clinical trials for the compound are planned for later this year.

(Scripps Research Institute) An international team of scientists from the Scripps Research Institute in California and the National Research Institute for Child Health and Development in Japan has discovered that a natural molecule in the body counters the progression of osteoarthritis. The findings could one day lead to new therapies for some common diseases of aging.

(Scripps Research Institute) Scientists at The Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation have shed new light on the molecular mechanism that enables us to sense temperature, such as the heat from a sizzling stove. In addition to contributing to our knowledge of basic biology, the findings could one day lead to new therapies for conditions such as acute or chronic inflammatory pain.

(Scripps Research Institute) In a joint study, scientists from The Scripps Research Institute and Harvard University's Dana-Farber Cancer Institute have established a new class of anti-diabetic compound that targets a unique molecular switch.

(Institut Pasteur Korea) Institut Pasteur Korea has signed an agreements to continue to mine the chemical compound collection of Novartis Institute for Tropical Diseases of Singapore for new drug candidates. IP-K's PhenomicScreen is a high-throughput, high-content visual screening platform that is ideally suited to identifying lead compounds.

(Scripps Research Institute) Scientists at The Scripps Research Institute have discovered a potential new use for the drug closantel, currently the standard treatment for sheep and cattle infected with liver fluke. The new research suggests that the drug may be useful in combating river blindness, a tropical disease that is the world's second leading infectious cause of blindness for humans.

(Scripps Research Institute) A team of scientists at the Scripps Research Institute has identified two compounds that act on novel binding sites for an enzyme used by the human immunodeficiency virus (HIV), the virus that causes AIDS. The discovery lays the foundation for the development of a new class of anti-HIV drugs to enhance existing therapies, treat drug-resistant strains of the disease, and slow the evolution of drug resistance in the virus.

(Scripps Research Institute) Discoveries by Scripps Research Institute scientists have led to a promising new drug candidate -- the first in its class -- for patients with a genetic protein-misfolding disease. In results announced by the biopharmaceutical firm FoldRx Pharmaceuticals, Inc. today, the new drug tafamidis significantly halts disease progression for patients with a disease called Transthyretin (TTR) amyloid polyneuropathy (ATTR-PN).