BiotechMashup

by Marta Curriu, Hughes Fausther-Bovendo, María Pernas, Marta Massanella, Jorge Carrillo, Cecilia Cabrera, Cecilio López-Galíndez, Bonaventura Clotet, Patrice Debré, Vincent Vieillard, Julià Blanco
Background CD4 T-cell decay is variable among HIV-infected individuals. In exceptional cases, CD4 T-cell counts remain stable despite high plasma viremia. HIV envelope glycoprotein (Env) properties, namely tropism, fusion or the ability to induce the NK ligand NKp44L, or host factors that modulate Env cytopathic mechanisms may be modified in such situation. Methods We identified untreated HIV-infected individuals showing non-cytopathic replication (VL>10,000 copies/mL and CD4 T-cell decay